Sunday 24th April 2022
Sunday 17th April 2022
| Trafford MV Ladies | h | h | Bury Ladies | ||
| h | |||||
Sunday 10th April 2022
| Upper Eden Ladies | 102 | 5 | Winnington Park Ladies |
| Workington Ladies | 27 | 17 | Bury Ladies |
Saturday 9th April 2022
| Trafford MV Ladies | 36 | 19 | Oldham Ladies |
Sunday 3rd April 2022
| Bury Ladies | 29 | 24 | Trafford MV Ladies |
| Southport Ladies | h | h | Burnley Ladies | ||
| h | |||||
Saturday 2nd April 2022
| Oldham Ladies | 19 | 48 | Upper Eden Ladies |
Sunday 27th March 2022
| Bury Ladies | h | h | Burnley Ladies | ||
| h | |||||
Sunday 20th March 2022
| Upper Eden Ladies | 85 | 7 | Bury Ladies |
| Winnington Park Ladies | 15 | 38 | Oldham Ladies |
Sunday 13th March 2022
| Burnley Ladies | 29 | 47 | Upper Eden Ladies |
| Oldham Ladies | 0 | 47 | Workington Ladies |
| Winnington Park Ladies | 5 | 41 | Trafford MV Ladies |
Sunday 6th March 2022
| Burnley Ladies | a | a | Workington Ladies | ||
| a | |||||
| Bury Ladies | 96 | 27 | Winnington Park Ladies |
| Upper Eden Ladies | 43 | 5 | Oldham Ladies |
Saturday 5th March 2022
| Southport Ladies | 55 | 0 | Trafford MV Ladies |
Sunday 27th February 2022
| Oldham Ladies | h | h | Bury Ladies | ||
| h | |||||
| Trafford MV Ladies | 76 | 20 | Burnley Ladies |
| Upper Eden Ladies | 21 | 41 | Southport Ladies |
Sunday 20th February 2022
| Burnley Ladies | P | P | Winnington Park Ladies |
| Trafford MV Ladies | P | P | Bury Ladies |
Sunday 13th February 2022
Sunday 6th February 2022
| Burnley Ladies | P | P | Upper Eden Ladies |
| Southport Ladies | h | h | Winnington Park Ladies | ||
| h | |||||
| Workington Ladies | 7 | 0 | Trafford MV Ladies |
Sunday 30th January 2022
| Southport Ladies | h | h | Oldham Ladies | ||
| h | |||||
| Winnington Park Ladies | P | P | Burnley Ladies |
Saturday 29th January 2022
| Upper Eden Ladies | 8 | 24 | Workington Ladies |
Sunday 23rd January 2022
| Trafford MV Ladies | P | P | Bury Ladies |
Sunday 16th January 2022
| Burnley Ladies | 25 | 31 | Oldham Ladies |
| Southport Ladies | 80 | 0 | Bury Ladies |
| Trafford MV Ladies | 53 | 7 | Upper Eden Ladies |
| Workington Ladies | 43 | 0 | Winnington Park Ladies |
Sunday 9th January 2022
| Bury Ladies | P | P | Burnley Ladies |
| Oldham Ladies | P | P | Workington Ladies |
| Winnington Park Ladies | P | P | Trafford MV Ladies |
Sunday 19th December 2021
| Burnley Ladies | 5 | 87 | Southport Ladies |
| Trafford MV Ladies | P | P | Bury Ladies |
| Upper Eden Ladies | P | P | Oldham Ladies |
Sunday 5th December 2021
| Bury Ladies | 22 | 14 | Upper Eden Ladies |
| Oldham Ladies | 36 | 20 | Winnington Park Ladies |
| Southport Ladies | 56 | 0 | Workington Ladies |
Sunday 28th November 2021
| Trafford MV Ladies | 0 | 19 | Southport Ladies |
| Winnington Park Ladies | 28 | 38 | Bury Ladies |
| Workington Ladies | P | P | Burnley Ladies |
Sunday 14th November 2021
| Burnley Ladies | 12 | 48 | Trafford MV Ladies |
| Bury Ladies | 29 | 26 | Oldham Ladies |
| Southport Ladies | 50 | 0 | Upper Eden Ladies |
Sunday 7th November 2021
| Oldham Ladies | A | A | West Park Leeds Ladies II - Withdrawn |
| Trafford MV Ladies | 29 | 15 | Workington Ladies |
| Upper Eden Ladies | 43 | 10 | Burnley Ladies |
| Winnington Park Ladies | 5 | 97 | Southport Ladies |
Sunday 24th October 2021
| Burnley Ladies | P | P | Winnington Park Ladies |
| Southport Ladies | h | h | Oldham Ladies | ||
| h | |||||
| Workington Ladies | 17 | 5 | Upper Eden Ladies |
Sunday 17th October 2021
| Bury Ladies | 24 | 59 | Southport Ladies |
| Oldham Ladies | 42 | 5 | Burnley Ladies |
| Upper Eden Ladies | 10 | 5 | Trafford MV Ladies |
| Winnington Park Ladies | 12 | 5 | Workington Ladies |
Sunday 3rd October 2021
| Burnley Ladies | 0 | 58 | Bury Ladies |
| Trafford MV Ladies | 45 | 0 | Winnington Park Ladies |
| Workington Ladies | P | P | Oldham Ladies |
Sunday 26th September 2021
| Bury Ladies | 17 | 25 | Workington Ladies |
| Oldham Ladies | 10 | 75 | Trafford MV Ladies |
| Winnington Park Ladies | 10 | 29 | Upper Eden Ladies |